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Phase 2Not yet recruitingNCT06227221

Sorafenib in new-onset T1D

What this study tests

Small (estimated enrollment 10) phase 2 randomized placebo-controlled study testing whether 26 weeks of sorafenib preserves mixed-meal-stimulated C-peptide in adults with new-onset type 1 diabetes, per the registry.

Editorial review: .

Registry checked: 2026-09-17. Registry’s own update: 2026-02-12.

Source dates appear in the references where available; this record has no dated citation metadata.

Trial status, labels and access can change between reviews. How we review the evidence · How to read the evidence

Full sources ↓Full discussion ↓Report an issue →

Evidence at a glance

Who can enter the study?
Adults 18–60 with T1D diagnosed per ADA criteria within 1 year before starting study drug, positive for at least one of GADA, IA-2A or ZnT8A, with stimulated C-peptide above 200 pmol/L, per the registry. The 26-week C-peptide outcome does not establish clinical benefit before results are available. Registered eligibility ↗Enrollment criteria describe who may enter. They do not establish who was analyzed or the denominator for a reported result.
Reported benefit and results
No results posted yet; per the registry the study is not yet recruiting (last update posted 12 February 2026).Read the result sources and their limitations →
Important harms
Read the reported results, safety discussion and original sources. A separate harms summary is not available; this does not establish safety.
Research access and approval
Study regions: Other regions. A trial listing does not establish product approval or current recruitment at a particular site. Check the study’s current entry requirements.
What remains uncertain?
Read the full discussion and original sources for study limitations. Planned endpoints and completion dates are not results.

Research status alone does not establish approval, clinical benefit or local availability.

Primary endpoints

  • Change from baseline of serum C-peptide AUC over 2 hours following a mixed meal, measured at week 26, per the registry

The full picture

This record has no longer discussion. Use the study criteria, reported results and original sources on this page to assess what is known and what remains unresolved.

Sources

  1. [1]