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Phase 1/2RecruitingNCT07199946

Verapamil to preserve residual insulin secretion in children

What this study tests

Phase 1/2 pediatric trial of verapamil for residual insulin preservation after recent-onset T1D.

Editorial review: .

Registry checked: 2026-09-17. Registry’s own update: 2025-09-30.

Source dates appear in the references where available; this record has no dated citation metadata.

Trial status, labels and access can change between reviews. How we review the evidence · How to read the evidence

Full sources ↓Full discussion ↓Report an issue →

Evidence at a glance

Who can enter the study?
Children aged 4 to under 10 at T1D diagnosis, diagnosed within the previous three months, with residual C-peptide and a diabetes autoantibody. The protocol excludes cardiac disease, abnormal ECG or blood-pressure history and specified interacting treatments; see the registry for the complete criteria. Registered eligibility ↗Enrollment criteria describe who may enter. They do not establish who was analyzed or the denominator for a reported result.
Reported benefit and results
No results posted yet.Read the result sources and their limitations →
Important harms
Read the reported results, safety discussion and original sources. A separate harms summary is not available; this does not establish safety.
Research access and approval
Study regions: European Union. A trial listing does not establish product approval or current recruitment at a particular site. Check the study’s current entry requirements.
What remains uncertain?
Read the full discussion and original sources for study limitations. Planned endpoints and completion dates are not results.

Research status alone does not establish approval, clinical benefit or local availability.

Primary endpoints

  • Change in C-peptide AUCmean 0-120 min) during an MMTT from baseline to month 24.
  • Number of participants with treatment-related adverse events as assessed by CTCAE v4.0".

The full picture

This record has no longer discussion. Use the study criteria, reported results and original sources on this page to assess what is known and what remains unresolved.

Sources

  1. [1]